Monday, January 23, 2012

Smoking During Pregnancy Not Linked to Autism (HealthDay)

FRIDAY, Jan. 20 (HealthDay News) -- Children born to women who smoke during pregnancy are not at increased risk for autism, according to a new study.

Smoking during pregnancy has been considered a possible cause of autism in children due to known links between smoking and behavioral disorders and obstetric complications, but previous studies of a connection between smoking during pregnancy and autism have had mixed results.

In this study, researchers analyzed data from nearly 4,000 Swedish children with autism and a control group of 39,000 children without autism. The results showed that 19.8 percent of the children in the autism group and 18.4 percent of those in the control group had mothers who smoked during pregnancy.

The study was published online in December in the Journal of Autism and Developmental Disorders and will appear in a upcoming print issue.

"We found no evidence that maternal smoking during pregnancy increases the risk of autism spectrum disorders," study leader Brian Lee, an epidemiologist at the School of Public Health at Drexel University in Philadelphia, said in a university news release.

"Past studies that showed an association were most likely influenced by social and demographic factors such as income and occupation that have associations with both the likelihood of smoking and with the rate of autism spectrum disorders," he added.

Lee said the findings help reassure mothers who smoked during pregnancy that their behavior likely didn't cause their child's autism and "crosses off another suspect on the list of possible environmental risk factors for ASD (autism spectrum disorders)."

However, he reminded women that smoking during pregnancy is unhealthy for mothers and has known risks for their children.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about autism.

Source: http://us.rd.yahoo.com/dailynews/rss/parenting/*http%3A//news.yahoo.com/s/hsn/20120121/hl_hsn/smokingduringpregnancynotlinkedtoautism

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HDNet joins up with AEG, CAA and Ryan Seacrest to become AXS TV this summer

It held on as long as it could, but HDNet is following the path of INHD (which became Mojo before disappearing entirely) and Discovery HD Theater (now Velocity) by rebranding itself, and will see itself morph into AXS TV this summer. Of course, HDNet has always focused on "lifestyle programming" and from the looks of it the new channel (pronounced: access) will be very similar, at least for now. HDNet is bringing programming like HDNet Fights, Dan Rather Reports, its concerts and more to the joint venture, which will be combined with its partners AEG, CAA and Ryan Seacrest Media. If HDNet is currently on your programming lineup AXS TV will simply take its place when it launches, and Dish Network actually plans to increase the channel's distribution by adding it to the America's Top 120 package. If you're distressed over the future of Art Mann Presents, check out the press release after the break or a Q&A on the site for more information about what's happening to Mark Cuban's baby.

Continue reading HDNet joins up with AEG, CAA and Ryan Seacrest to become AXS TV this summer

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/HBGCWnhg2SA/

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Sunday, January 22, 2012

Israeli leader condemns Palestinian Muslim cleric

FILE- In this Sept. 19, 2006, file photo, the Mufti of Jerusalem Mohammed Hussein, speaks during a media conference in the West Bank town of Ramallah. Mufti Hussein, the Palestinians' top Muslim cleric, is facing harsh Israeli criticism for quoting a religious text that includes passages about killing Jews. Hussein said his remarks at a rally for Palestinian President Mahmoud Abbas' Fatah movement last week were taken out of context and that he didn't incite people to kill Jews.(AP Photo/Muhammed Muheisen, File)

FILE- In this Sept. 19, 2006, file photo, the Mufti of Jerusalem Mohammed Hussein, speaks during a media conference in the West Bank town of Ramallah. Mufti Hussein, the Palestinians' top Muslim cleric, is facing harsh Israeli criticism for quoting a religious text that includes passages about killing Jews. Hussein said his remarks at a rally for Palestinian President Mahmoud Abbas' Fatah movement last week were taken out of context and that he didn't incite people to kill Jews.(AP Photo/Muhammed Muheisen, File)

Israeli Prime Minister Benjamin Netanyahu, center, convenes the weekly cabinet meeting in Jerusalem, Sunday, Jan. 22, 2012. Also seen in the picture are Israeli Information Minister Yuli Edelstein, left, and cabinet secretary Tzvi Hauser, right. (AP Photo/Abir Sultan, Pool)

JERUSALEM (AP) ? The Palestinians' top Muslim cleric faced sharp Israeli criticism Sunday for a speech in which he quoted a religious text that includes passages about killing Jews in an end-of-days struggle.

Mufti Mohammed Hussein's comments came at a political gathering of supporters of Palestinian President Mahmoud Abbas. He said his remarks were taken out of context and that he didn't incite people to kill Jews. But by speaking at the venue, Hussein appeared to be linking the battle to the conflict with Israel.

"The hour of resurrection will not come until you fight the Jews," Hussein told the gathering, citing a hadith, or saying attributed to the Prophet Muhammad. "The Jews will hide behind stones and trees. But the trees and the stones will call: oh Muslim, oh servant of God, there is a Jew hiding behind me so come and kill him."

In a separate development, Israel's prime minister, Benjamin Netanyahu, said he hoped to reach a compromise with settlers that would stave off a looming deadline to evacuate the largest unauthorized settlement outpost in the West Bank.

The Supreme Court, ruling that Migron was built on private Palestinian land, has ordered the outpost to be uprooted by March 31. With residents vowing to defy the evacuation, Netanyahu suggested they be moved to nearby land that is not privately owned.

An Israeli official said the proposal, which would need Supreme Court approval, aims to avert a violent standoff with the settlers. But Peace Now, an anti-settlement watchdog group, said the proposal was merely a stalling tactic.

A spokesman for the residents, Itai Chemo, rejected the proposal. "Relocation is not an answer to these attacks," he said. Instead, he called for a "brave dialogue" with the government to find a "proper solution."

The Israeli official, speaking on condition of anonymity because he was discussing internal government plans, said the settlement would be uprooted by March 31 if the residents do not agree to move.

The mufti delivered his three-minute speech on Jan. 7 in an Arab neighborhood of east Jerusalem during celebrations of the 47th anniversary of the Palestinian movement Fatah, said Itamar Marcus of Palestine Media Watch, an Israeli watchdog group that tracks incitement.

Marcus' group posted excerpts of the speech on YouTube last week. The comments drew angry reactions from Israelis on Sunday.

"We're talking about a heinous offense that all nations of the world must condemn," Prime Minister Benjamin Netanyahu said in a statement sent to reporters by text message. He asked the Israeli attorney general to launch an investigation.

It is unclear what authority Israel would have since Hussein is appointed to his position by the Palestinian president. There was no immediate comment from Abbas' office.

Hussein, who is based in Jerusalem, said his comments were taken out of context.

"I was speaking about the final signs of the day of resurrection," Hussein said. "I did not incite, and I did not call for killing. We are not, at present, at the end of days."

The Quran, Islam's holy book, offers contradictory attitudes toward Jews and Christians. There are texts that enshrine tolerance and respect for other faiths, while others are spiked with hatred and incitement.

Some extremist rabbis also have found passages in Jewish texts that they believe justifies violence against the Palestinians.

Tensions between Israelis and the Palestinians have been fueled by a three-year breakdown in peace efforts. Talks broke down in late 2008 and have remained frozen over the issue of Israeli settlement construction in the West Bank and east Jerusalem, areas captured by Israel in the 1967 Mideast war and claimed by the Palestinians for a future state.

The Palestinians say there is no point in negotiating as long as Israel continues to build homes for its citizens on occupied land. Israel says the future of settlements is a matter for negotiations.

Some 500,000 Israeli settlers now live in the West Bank and east Jerusalem, and some communities deep in the West Bank are considered especially hard line.

Israeli and Palestinian negotiators resumed low-level contacts early this month with the aim of finding a formula for restarting formal negotiations. The Palestinians continue to insist that Israel freeze all settlement construction. Sunday's proposal to delay the evacuation of Migron is likely to harden Palestinian skepticism toward Netanyahu.

___

Diaa Hadid can be reached on twitter at http://twitter.com/diaahadid

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2012-01-22-ML-Israel-Palestinians/id-cb093e877b9348da83e28193342f9a04

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$356 Million Later, the Justice Department's Wireless Network Still Sucks [Feds]

After 9/11, three federal law enforcement agencies planned a massive project to replace a mishmash of aging and obsolete radios used by thousands of federal agents. A decade and $356 million later, the program has made "minimal progress" and the Department of Homeland Security, one of the project's key partners, wants little to do with it. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/iPpfPhYpjnM/356-million-later-the-justice-departments-wireless-network-still-sucks

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Saturday, January 21, 2012

Gingrich gets Perry nod, faces ex-wife allegations (AP)

BEAUFORT, S.C. ? In an up-and-down kind of campaign day, Republican presidential candidate Newt Gingrich picked up an endorsement Thursday from former rival Rick Perry but also faced new accusations from one of his former wives that he had asked her permission to have an "open marriage" after she learned he was having an affair.

The former House speaker also prepared to release his 2010 income tax returns, certain to bring fresh scrutiny to his campaign.

Two days before the pivotal South Carolina primary, Gingrich's political and private life were clashing just as new polls showed him rising as he looks to overtake GOP front-runner Mitt Romney in the third state to weigh in on the presidential race. Gingrich has seen his crowds grow in recent days after a strong performance in a debate Monday.

With the second debate of the week looming Thursday night, it was unclear how the new revelations from Marianne Gingrich would play in a state where religious and socially conservative voters hold sway.

Equally uncertain was whether Gingrich would get a boost from Perry's endorsement, given that the Texas governor had little support in the state, and get conservative voters to coalesce behind his candidacy. Complicating Gingrich's effort is another conservative, Rick Santorum, who threatens to siphon his support.

"Newt is not perfect but who among us is," Perry said as he bowed out of the race and called Gingrich a "conservative visionary."

It was all but certainly intended to counter the interview with Marianne Gingrich, her first on television since the divorce from Gingrich in 2000, that ABC News was set to broadcast Thursday night.

In excerpts the network released before the broadcast, Marianne Gingrich said that when she learned of Gingrich's affair with Callista Bisek, a congressional staffer, he asked his wife to share him.

"And I just stared at him and he said, `Callista doesn't care what I do,'" Gingrich' second wife said. "He wanted an open marriage and I refused."

Gingrich brushed aside reporters' questions after a campaign event along the waterfront in Beaufort, S.C. on Thursday.

"Look, I'm not going to say anything about Marianne. My two daughters have already written to ABC complaining about this as tawdry and inappropriate," he said.

Gingrich has said in the past that tough questions are fair game for a candidate running for president. But on Thursday he referred all queries about his second marriage to his two daughters from his first marriage.

"I'm not getting involved," he said.

The television interview with Marianne Gingrich threw a wild card into the race in its final hours.

Its mere existence shines a spotlight on a part of Gingrich's past that could turn off Republican voters in a state filled with religious and cultural conservatives who may cringe at his two divorces and acknowledged marital infidelities.

Marianne Gingrich has said Gingrich proposed to her before the divorce from his first wife was final in 1981; they were married six months later. Her marriage to Gingrich ended in divorce in 2000, and Gingrich has admitted he'd already taken up with Callista Bisek, a former congressional aide who would become his third wife. The speaker who pilloried President Bill Clinton for his affair with Monica Lewinsky was himself having an affair at the time.

Underscoring the potential threat to his rise, Gingrich's campaign released a statement from his two daughters from his first marriage ? Kathy Lubbers and Jackie Cushman ? suggesting that Marianne Gingrich's comments may be suspect given the emotional toll divorce takes on everyone involved.

"Anyone who has had that experience understands it is a personal tragedy filled with regrets and sometimes differing memories of events," their statement said.

A CNN/Time South Carolina poll released Wednesday showed Gingrich in second place with support from 23 percent of likely primary voters, having gained 5 percentage points in the past two weeks. Romney led in the poll with 33 percent, but he had slipped some since the last survey. Santorum was third, narrowly ahead of Texas Rep. Ron Paul and well ahead of Perry.

Regardless of the South Carolina outcome, Gingrich was making plans to compete in Florida's primary on Jan. 31.

Confidence exuded from Gingrich, who rose in Iowa only to be knocked off course after sustaining $3 million in attack ads in Iowa from an outside group that supports Romney. Gingrich posted dismal showings in both Iowa and New Hampshire.

By the time the race turned to South Carolina, he was sharply criticizing Romney as a social moderate who is timid about attacking the nation's economic troubles. He also raised questions about Romney's experience as a venture capitalist, while a super PAC that supports Gingrich aggressively attacked Romney as a vicious corporate raider. Gingrich also ripped Romney for standing by as a super PAC run by former top Romney political aides continued to attack him in South Carolina.

Romney ended up on the defensive and by Monday night's debate, Gingrich was back in command. He earned a standing ovation when he labeled Democratic President Barack Obama "the best food stamp president in American history." The clip became the centerpiece of a television ad that began airing Wednesday as Gingrich worked to cast himself as the Republican with the best chance of beating Obama in the fall, stealing a page from Romney's playbook.

Said Gingrich senior adviser David Winston: "His taking on Barack Obama showed a toughness and an electability that the electorate is looking for."

Since then, Romney's campaign, sensing Gingrich's rise and working to deflect from its own troubles, has been trying to undercut Gingrich's claim that he helped President Ronald Reagan create millions of jobs in the 1980s, likening it to "Al Gore taking credit for the Internet."

Romney also dispatched supporters to make the case that Gingrich is erratic and unreliable. A new Romney Web video features former Republican Rep. Susan Molinari of New York saying Gingrich lacked discipline and labeling his time as speaker "leadership by chaos."

Gingrich, for his part, has been helped by the fact that Santorum has seemed unable to capitalize on the endorsement of a group of influential Christian conservatives. Those who aren't backing the former Pennsylvania senator seem to be coming Gingrich's way.

Source: http://us.rd.yahoo.com/dailynews/rss/us/*http%3A//news.yahoo.com/s/ap/20120119/ap_on_el_pr/us_gingrich

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Radiation-induced damage to brain tissue reversed by oxygen starvation in mice

Thursday, January 19, 2012

Treating brain tumors with whole brain radiation therapy can damage healthy brain tissue, but a new study in mice reveals that limiting the oxygen supply, or hypoxia, can alleviate some of the cognitive impairment caused by the radiation. The results are reported in the Jan. 18 issue of the online journal PLoS ONE.

The researchers, led by William Sonntag of University of Oklahoma, exposed the mice to a clinically relevant regimen of radiation, which caused progressive deterioration of spatial learning starting about two months post-radiation.

However, when mice were treated with chronic hypoxia for about three weeks, beginning one month after radiation exposure, they showed significant improvement in this area, which was maintained for at least two months after returning to normal oxygen levels.

The radiation treatment also caused an early decline in contextual learning and memory, but these deficiencies were transient and dissipated within three months post-radiation.

###

Warrington JP, Csiszar A, Mitschelen M, Lee YW, Sonntag WE (2012) Whole Brain Radiation-Induced Impairments in Learning and Memory Are Time-Sensitive and Reversible by Systemic Hypoxia. PLoS ONE 7(1): e30444. doi:10.1371/journal.pone.0030444

Public Library of Science: http://www.plos.org

Thanks to Public Library of Science for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/116851/Radiation_induced_damage_to_brain_tissue_reversed_by_oxygen_starvation_in_mice

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Friday, January 20, 2012

Study showed oxaliplatin improved colon cancer patient survival

Study showed oxaliplatin improved colon cancer patient survival [ Back to EurekAlert! ] Public release date: 20-Jan-2012
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Contact: Zachary Rathner
Zachary.Rathner@oup.com
301-841-1286
Journal of the National Cancer Institute

Stage III colon cancer patients in the general population who receive adjuvant treatment for the disease have an improved rate of survival when oxaliplatin is added to 5-fluorouracil (5FU), according to a study published Jan. 20 in the Journal of the National Cancer Institute.

Colon cancer is a leading global cause of both illness and death; with an estimated 101,340 cases among Americans in 2011. Roughly one third of diagnoses are stage III or node-positive disease. In randomized clinical trials (RCTs), adding oxaliplatin to adjuvant 5FU is known to improve outcomes of patients with stage III colon cancer. But the effect of this combined therapy outside RCTs is unknown. In addition, fewer than 2% of patients with the cancer enroll in RCTs, and participants are known to be generally younger, healthier and less racially diverse than the overall cancer patient population.

In order to determine the effects of combined therapy in stage III colon cancer patients in the general population, Hanna K. Sanoff M.D., and assistant professor of Medicine, Hematology and Oncology at the University of Virginia School of Medicine and colleagues, gathered data from patients using the Surveillance, Epidemiology, and End Results registry linked to Medicare claims (SEER-Medicare), among other cancer registries. All patients had stage III colon cancer, received chemotherapy within 120 days of surgery, and were age 75 years or younger. Overall survival (OS) was then compared between patients treated with combined therapy and standard chemotherapy.

The researchers found that adding oxaliplatin to adjuvant therapies for stage III colon cancer in patients of the general cancer population was just as effective as in patients from RCTs. The addition of oxaliplatin showed improved survival across various practice settings, including those with older and minority patients as well as patients with greater comorbidity. "Physicians and patients should be reassured from our findings that oxaliplatin is associated with marginally but consistently superior survival for patients diagnosed before age 75 years in community settings," the authors write. They feel that now that combined therapy has proven efficacious in the general population, it is important to home in on high risk subgroups such as patients over age 75, racially diverse minorities, and those with co morbid conditions.

###

Contact: Deborah Schrag, deb_schrag@dfci.harvard.edu


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Study showed oxaliplatin improved colon cancer patient survival [ Back to EurekAlert! ] Public release date: 20-Jan-2012
[ | E-mail | Share Share ]

Contact: Zachary Rathner
Zachary.Rathner@oup.com
301-841-1286
Journal of the National Cancer Institute

Stage III colon cancer patients in the general population who receive adjuvant treatment for the disease have an improved rate of survival when oxaliplatin is added to 5-fluorouracil (5FU), according to a study published Jan. 20 in the Journal of the National Cancer Institute.

Colon cancer is a leading global cause of both illness and death; with an estimated 101,340 cases among Americans in 2011. Roughly one third of diagnoses are stage III or node-positive disease. In randomized clinical trials (RCTs), adding oxaliplatin to adjuvant 5FU is known to improve outcomes of patients with stage III colon cancer. But the effect of this combined therapy outside RCTs is unknown. In addition, fewer than 2% of patients with the cancer enroll in RCTs, and participants are known to be generally younger, healthier and less racially diverse than the overall cancer patient population.

In order to determine the effects of combined therapy in stage III colon cancer patients in the general population, Hanna K. Sanoff M.D., and assistant professor of Medicine, Hematology and Oncology at the University of Virginia School of Medicine and colleagues, gathered data from patients using the Surveillance, Epidemiology, and End Results registry linked to Medicare claims (SEER-Medicare), among other cancer registries. All patients had stage III colon cancer, received chemotherapy within 120 days of surgery, and were age 75 years or younger. Overall survival (OS) was then compared between patients treated with combined therapy and standard chemotherapy.

The researchers found that adding oxaliplatin to adjuvant therapies for stage III colon cancer in patients of the general cancer population was just as effective as in patients from RCTs. The addition of oxaliplatin showed improved survival across various practice settings, including those with older and minority patients as well as patients with greater comorbidity. "Physicians and patients should be reassured from our findings that oxaliplatin is associated with marginally but consistently superior survival for patients diagnosed before age 75 years in community settings," the authors write. They feel that now that combined therapy has proven efficacious in the general population, it is important to home in on high risk subgroups such as patients over age 75, racially diverse minorities, and those with co morbid conditions.

###

Contact: Deborah Schrag, deb_schrag@dfci.harvard.edu


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-01/jotn-sso011812.php

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